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. 2018 Sep 18;16(5):6465–6471. doi: 10.3892/ol.2018.9445

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Copyright: © Qiu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — LKB1 downregulates ZEB1 expression in Hep3B cells. (A) RT-qPCR and (B) western blotting (B) results demonstrated that overexpression of LKB1 inhibited the expression of ZEB1 but no other EMT-inducing genes in Hep3B cells. (C) Western blot analysis demonstrated that overexpression of LKB1 increased the expression of E-cadherin and decreased the expression of vimentin in Hep3B cells. (D) Western blot analysis demonstrated that the knockdown of LKB1 increased the expression of ZEB1 and decreased the expression of E-cadherin in CRL-11233 cells. *P<0.05; **P<0.01; ***P<0.001. LKB1, liver kinase B1; EMT, epithelial-mesenchymal transition; ZEB1, Zinc Finger E-Box Binding Homeobox 1; RT-qPCR, reverse transcription-quantitative polymerase chain reaction.