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. 2018 Sep 18;16(5):6465–6471. doi: 10.3892/ol.2018.9445

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Copyright: © Qiu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — EMT induced by LKB1 loss promotes HCC migration and invasion through ZEB1. (A) Knockdown of LKB1 promotes the motility of CRL-11233 cells compared with the scramble control RNA. Knockdown of ZEB1 in LKB1 depleted CRL-11233 cells partially inhibits motility of CRL-11233. (B) Knockdown of ZEB1 inhibits the migration of Hep3B cells. (C) Knockdown of ZEB1 inhibits the invasiveness of Hep3B cells. Data are expressed as the mean numbers of independent triplicate experiments. ***P<0.001; **P<0.01. scr, scramble; ZEB1, Zinc Finger E-Box Binding Homeobox 1; LKB1, liver kinase B1; si, small interfering.