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. 2018 Sep 18;16(5):6465–6471. doi: 10.3892/ol.2018.9445

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Copyright: © Qiu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — ZEB1 regulates the expression of YAP to promote YAP signaling. (A) RT-qPCR showed the effect of ZEB1 on YAP expression. Data are expressed as the mean numbers of independent triplicate experiments. **P<0.01. (B) Western blotting results demonstrated that knockdown of ZEB1 inhibited the expression of YAP and YAP target genes in the Hep3B cell line. (C) A Luciferase reporter assay demonstrated that ZEB1 expression increased the reporter activity of the YAP promoter in Hep3B cells. Data are expressed as the mean numbers of independent triplicate experiments. **P<0.01. ZEB1, Zinc Finger E-Box Binding Homeobox 1; YAP, Yes-associated protein; RT-qPCR, reverse transcription quantitative polymerase chain reaction; scr, scramble; si, small interfering.