Table I.

GO annotation of DEGs in PCa.

A, Upregulated genes
Category	Term/gene function	Count	P-value
GOTERM_BP_FAT	Cellular response to growth factor stimulus	27	4.7×10-6
GOTERM_BP_FAT	Regulation of phosphate metabolic process	25	6.2×10-6
GOTERM_BP_FAT	Cell development	54	6.3×10-5
GOTERM_BP_FAT	Regulation of cell cycle	28	3.1×10-3
GOTERM_BP_FAT	Cell division	19	3.7×10-3
GOTERM_CC_FAT	Contractile fiber	20	5.4×10-9
GOTERM_CC_FAT	Actin cytoskeleton	25	9.6×10-7
GOTERM_CC_FAT	Anchoring junction	31	2.5×10-6
GOTERM_CC_FAT	Adherens junction	30	4.6×10-6
GOTERM_CC_FAT	Focal adhesion	21	9.4×10-6
GOTERM_MF_FAT	Enzyme binding	53	6.1×10-6
GOTERM_MF_FAT	Cytoskeletal protein binding	31	9.0×10-3
GOTERM_MF_FAT	Enzyme regulator activity	30	9.5×10-4
GOTERM_MF_FAT	Macromolecular complex binding	34	3.9×10-3
GOTERM_MF_FAT	Protein kinase binding	18	4.4×10-3
B, Downregulated genes
Category	Term/gene function	Count	P-value
GOTERM_BP_FAT	Regulation of signal transduction	25	9.2×10-6
GOTERM_BP_FAT	Regulation of cell communication	25	3.9×10-5
GOTERM_BP_FAT	Regulation of response to stimulus	27	4.6×10-5
GOTERM_BP_FAT	Cell projection organization	26	5.4×10-5
GOTERM_BP_FAT	Cell development	33	1.0×10-4
GOTERM_CC_FAT	Membrane raft	11	2.6×10-4
GOTERM_CC_FAT	Actin cytoskeleton	12	2.6×10-3
GOTERM_CC_FAT	Adherens junction	14	7.5×10-3
GOTERM_CC_FAT	Anchoring junction	14	9.1×10-3
GOTERM_CC_FAT	Membrane-bounded vesicle	44	1.2×10-3
GOTERM_MF_FAT	RNA binding	43	9.3×10-6
GOTERM_MF_FAT	Cytoskeletal protein binding	17	1.1×10-4
GOTERM_MF_FAT	Enzyme regulator activity	18	2.3×10-3
GOTERM_MF_FAT	Transcription factor binding	11	7.7×10-3
GOTERM_MF_FAT	Calcium ion binding	12	2.9×10-3

GO, gene ontology; PCa, prostate cancer; DEGs, differentially expressed genes.