Table II.
KEGG pathway analysis of DEGs in PCa.
| A, Upregulated genes | |||
|---|---|---|---|
| KEGG terms | Count | P-value | Genes |
| Proteoglycans in cancer | 13 | 5.0×10-5 | IQGAP1, ROCK2, ARHGEF12, TIMP3, CAV1, CAV2, FZD1, HOXD10, PAK1, PPP1R12A, PPP1R12B, SDC4, TGFB2 |
| Endocytosis | 12 | 1.9×10-4 | SH3GLB1, VPS37A, ARRB1, CAV1, CAV2, CHMP1B, CHMP7, SNX2, SPG20, TGFB2, TGFB3, VPS36 |
| Focal adhesion | 10 | 4.2×10-3 | ROCK2, CAV1, CAV2, COL4A6, CCND2, MYLK, PAK1, PPP1R12A, PPP1R12B, VCL |
| Hippo signaling pathway | 8 | 8.3×10-3 | MOB1A, WWTR1, YAP1, CCND2, FZD1, SNAI2, TGFB2, TGFB3 |
| cGMP-PKG signaling pathway | 8 | 1.4×10-3 | GNAI2, ROCK2, CALM1, CALM3, MEF2A, MYLK, NPR2, PPP1R12A |
| B, Downregulated genes | |||
| KEGG terms | Count | P-value | Genes |
| Proteoglycans in cancer | 8 | 1.6×10-3 | IQGAP1, ARHGEF12, TIMP3, CAV1, CAV2, FZD1, HOXD10, SDC4 |
| Endocytosis | 6 | 7.2×10-3 | SH3GLB1, VPS37A, ARRB1, CAV1, CAV2, SPG20 |
| Hippo signaling pathway | 5 | 4.2×10-2 | MOB1A, WWTR1, YAP1, FZD1, SNAI2 |
| Thyroid hormone signaling pathway | 4 | 7.6×10-2 | SIN3A, FOXO1, RXRA, SLC16A2 |
| Sulfur relay system | 2 | 8.4×10-2 | MOCS1, MOCS2 |
KEGG, Kyoto Encyclopedia of Genes and Genomes; PCa, prostate cancer; DEGs, differentially expressed genes; FOXO1, forkhead box O1.