Table 2. Descriptions of the studies for screening of asymptomatic coronary artery disease in patients with diabetic mellitus.
| Variable | DIAD (2009) | FACTOR-64 (2014) | DADDY-D (2015) |
|---|---|---|---|
| No. of patients | 1,123 | 899 | 520 |
| Design of study | Randomized, multicenter | Randomized, multicenter | Randomized, multicenter |
| Countries | USA and Canada | USA | Italy |
| Duration of follow-up, yr | 5 | 4 | 3.6 |
| Screening method | SPECT | CCTA | ETT |
| Results of screening | |||
| No. of screening arm | 561 | 452 | 262 |
| Positive screening | 15 (83/561) | 17 (76/452) | 8 (20/262) |
| CAG related to positive screening | 4 (25/561) | 8 (36/452) | 6 (17/262) |
| Proportion of patients with positive screening who performed CAG | 30 (25/83) | 47 (36/76) | 85 (17/20) |
| Outcomes | |||
| Cardiovascular death | |||
| Screening | 1.4 (8/561) | 1.5 (7/452) | 0.4 (1/262) |
| No screening | 1.2 (7/562) | 1.8 (8/447) | 1.9 (5/258) |
| Nonfatal myocardial infarction | |||
| Screening | 1.3 (7/561) | 1.5 (7/452) | 4.2 (11/262) |
| No screening | 1.7 (10/562) | 1.8 (8/447) | 4.7 (12/258) |
| Coronary revascularization | |||
| Screening | 5.5 (31/561) | 5.8 (26/452) | 4.6 (12/262) |
| No screening | 7.8 (44/562) | 3.1 (14/447) | 8.5 (22/258) |
Values are presented as percentage (number/total number).
DIAD, Detection of Ischemia in Asymptomatic Diabetics; FACTOR-64, Screening for Asymptomatic Obstructive Coronary Artery Disease among High-Risk Diabetic Patients Using CT Angiography, Following Core 64; DADDY-D, Does Coronary Atherosclerosis Deserve to be Diagnosed Early in Diabetic Patients; SPECT, single-photon emission computed tomography; CCTA, coronary computed tomography angiography; ETT, exercise tolerance test; CAG, coronary angiography.