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. 2018 Oct 20;141(11):3144–3159. doi: 10.1093/brain/awy253

Figure 7.

Figure 7

Patient-derived LGI1 IgG alters synaptic plasticity. (A) Example traces of individual fEPSP recordings in the CA1 region before (black traces) and after (red traces) theta burst stimulation (TBS) of Schaffer collateral afferents. Potentiation of fEPSPs is reduced in brain slices of mice that received patient-derived LGI1 IgG without further changes upon application of DTX. (B) Time course of LTP after theta-burst stimulation (arrow), demonstrates persistent reduction of fEPSP slope values in slices of mice after infusion of patient-derived LGI1 IgG indicating disturbed synaptic plasticity. (C) Quantification of fEPSP slope change is decreased in LGI1 IgG infused mice. Application of DTX does not alter fEPSP slope values in LGI1 and control IgG infused mice, respectively (ncontrol IgG = 14; ncontrol IgG+DTX = 9; nLGI1 IgG = 18; nLGI1 IgG+DTX = 8; box plots show the median, 25th, and 75th percentiles; whiskers indicate the 10th and 90th percentiles, outlying points are depicted as dots; one-way ANOVA and Bonferroni post hoc test. *P < 0.05, **P < 0.01).