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. 2018 Oct 9;141(11):3233–3248. doi: 10.1093/brain/awy244

Figure 3.

Figure 3

Biomarker changes for persons who did and did not develop CDR > 0. Comparison of selected biomarker, structural, and clinical changes for persons who did and did not develop CDR > 0. Solid lines represent those who developed dementia and dotted lines indicate persons who remained cognitively normal. P-values indicate whether there was a significant difference in the mean slope of each group. Aβ = amyloid-β; ACA = arbitrary clinical assessment; MMSE = Mini-Mental State Examination; nHV = normalized hippocampal volume; nWBV = normalized whole brain volume. *No persons had MMSE scores >30, nor CDR Sum of Boxes scores < 0. Extension of lines across the x-axis for these measures is an artefact of the curve-fitting process.