Table 2.

Some major discoveries relating to HSV1 and AD between 2005 and 2018.

Discovery	Reference
Association of cognitive impairment with HSV1-seropositive APOE-ε4 in aged cardiovascular patients.	Strandberg et al. (2005)
HSV1 load/expression is greater in APOE-ε4 transgenic mice.	Burgos et al. (2006), Miller and Federoff (2008) Bhattacharjee et al. (2008)
Presence/levels of serum anti-HSV1 antibodies is associated with AD.	Letenneur et al. (2008) and Lövheim et al. (2015)
HSV1-infected cell cultures produce hyper-phosphorylated tau.	Zambrano et al. (2008)
Genetic links between HSV1 and host cells from GWAS.	Licastro et al. (2011), Carter (2013)
Aβ inhibits HSV1 DNA replication in cultured neuronal cells.	Bourgade et al. (2015)
HSV1 causes synaptic dysfunction if cultured cortical neurons.	Piacentini et al. (2015)
Lysosomal load increases and lysosomal function inpaired in HSV1-infected cell cultures.	Kristen et al. (2018)
HSV1-infection confers a risk of senile dementia and antiherpes antivirals strongly protect against SD.	Tzeng et al. (2018a)
High levels of HHV6 and 7 in AD brains HSV1& also HSV1, and they cause changes in several transcriptional regulators.	Readhead et al. (2018)
Aβ fibrillization occurs when Aβ oligomer enfolds HSV1 as a protective measure.	Eimer et al. (2018)