Table 2.
Anti-oncomirs in pathogenesis of renal cell carcinoma [1–40]
| MicroRNA | Target | Pathway/mechanism |
|---|---|---|
| miR-1 | TAGLN2 | Cell proliferation, invasion, apoptosis and cell cycle arrest |
| miR-20b-5p | VEGFA, PAR-1, MALAT1 | Cellular proliferation, migration and apoptosis |
| miR-22 | PTEN | Cell growth, migration and invasion |
| miR-23b | POX | HIF/apoptosis |
| miR-30c | Slug | VHL/HIF/epithelial-mesenchymal transition, cell migration |
| miR-30d | Cyclin E2 | Cyclin E2/cell proliferation and colony formation, G1 phase arrest |
| miR-34a | Notch1, GAS1 | Cell growth, cell cycle arrest |
| miR-99a | mTOR, IGF-1R | IGF-1R/G1-phase cell cycle arrest, cells growth, clonability, migration and invasion |
| miR-133a | TAGLN2 | Cell proliferation, invasion, apoptosis and cell cycle arrest |
| miR-133b | MMP-9 | Cell proliferation, migration and invasion |
| miR-133b miR-135a |
Bcl-2 | JAK2/STAT3/cell apoptosis |
| miR-135a | c-MYC | Cell cycle, pathways in cancer, DNA replication, and focal adhesion |
| miR-138 | HIF-1α, vimentin, EZH2 | HIF/ apoptosis and cell migration/cell senescence |
| miR-143 miR-145 |
HK2 | Cell proliferation and invasion |
| miR-145 | ADAM17, ANGPT2, NEDD9 | HIF2α/VEGF/MMP9/CCND1/ ARE/Cell proliferation and migration, G2-phase arrest |
| miR-148a | AKT2 | Cell proliferation, colony formation, migration and invasion |
| miR-182-5p | FLOT1 | AKT/FOXO3a/ proliferation, tumorigenicity, G1-phase arrest |
| miR-192 miR-194 |
MDM2, TYMS, ZEB2 | Cell proliferation and invasion |
| miR-199a-3p | HGF/c-Met | HGF/c-Met/cell proliferation and caused G1 phase arrest |
| miR-200c | ZEB1 | Akt /epithelial-to-mesenchymal transition modulation, metastatic ability |
| miR-205 | SFK, ZEB2 | Phospho-Src–regulated ERK1/2 pathway/ cell proliferation, colony formation, migration, and invasion |
| miR-206 | GAK | Cell proliferation, migration and invasion, cell cycle arrest |
| miR-215 | MDM2, TYMS, ZEB2 | Cell proliferation and invasion |
| miR-218 | Caveolin-2, CXCR7 | Focal Adhesion Pathway/cell viability, migration and invasion ability |
| miR-490-5p | PIK3CA | Tumourigenicity |
| miR-497 | VEGFR-2, ACHN | MEK/ERK, p38 MAPK/cell viability, migration and invasion |
| miR-508-3p miR-509-3p |
Cell invasion, migration and apoptosis | |
| miR-509-5p | FIGN, SFRS11, HMGA2, GOLGA1 | Cell migration, proliferation and anti-apoptosis |
| miR-584 | ROCK-1 | 3′UTR luciferase activity of ROCK-1/cell motility inhibition |
| miR-708 | ZEB2, BMI1 | Cell growth, clonability, invasion, migration and apoptosis |
| miR-1285 | TGM2 | Cell proliferation and invasion |
| miR-1291 | SLC2A1/GLUT1 | Cell proliferation, migration and invasion |
| miR-1826 | CTNNB1, MEK1 | Cell proliferation, invasion and migration, apoptosis and G 1 arrest in VHL-inactivated renal cancer cells |