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. 2018 Sep 19;20:1092–1105. doi: 10.1016/j.nicl.2018.09.011

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 8 — Effect of the coconut oil diet on SOD1^G93A mice.

(A) The effect of the coconut oil diet on weight in SOD1^G93A mice at the beginning of treatment (Day 70), day 90, day 110 and day 130 of the study. Coconut oil fed group had significant net positive effect on retention of body weight during P90 (P < 90), P110 (P < .001) and P130 (P < .0001). (B) The PaGE test showed better motor performance in the coconut oil diet group on week 14, 15 and 16 (P < .001, P < .0001, P < .0001, respectively), compared to the standard diet group. (C) Kaplan-Meier survival plot of the study groups. SOD1^G93A mice treated with coconut oil diet showed significantly extended survival (13.6%) compared to control animals (p < .0001). Data = mean ± SD; Coconut oil diet group: n = 6, standard diet group: n = 6. **P < .01, ***P < .001, **** P < .0001.