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. 2018 Sep 19;20:1092–1105. doi: 10.1016/j.nicl.2018.09.011

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 9 — The effects of coconut oil supplementation on hindbrain neurometabolite levels of SOD1^G93A mice assessed with ¹H-MRS.

(A–B) Neurometabolite profiles determined by in vivo MRS of the standard diet group and coconut oil diet group at day 70 and day 120. Significant decrease in creatine and NAA was found for the standard diet group between 70 and 120 days (P < .001, P < .005 respectively). No significant changes in neurometabolites were found for the coconut oil diet group between day 70 and day 120. (C) Comparison of the two groups at P120. Significant decrease in creatine was found for the standard diet group (P < .01) compared to the coconut oil diet group. (D) A highly significant (P < .0001) correlation (R² = 0.922) between the survival and the hindbrain NAA levels was seen for the two groups. Dotted circles highlight the standard diet and coconut oil diet groups.