Abstract P264 – Table 1. PK parameters of HIV ARVs and HCV DAAs when co‐administered
B/F/TAF+LDV/SOF | BIC | FTC | TAFa | TFV | SOF | GS‐331007 | LDV | |
---|---|---|---|---|---|---|---|---|
AUCtau | ↔ | ↔ | ↔ | 67%↑ | ↔ | ↔ | ↔ | |
Cmax | ↔ | ↔ | ↔ | 43%↑ | ↔ | ↔ | ↔ | |
Ctau | ↔ | ↔ | NR | 81%↑ | NR | ↔ | ↔ | |
B/F/TAF+SOF/VEL/VOX | BIC | FTC | TAFa | TFV | SOF | GS‐331007 | VEL | VOX |
AUCtau | ↔ | ↔ | 58%↑ | 67%↑ | ↔ | ↔ | ↔ | ↔ |
Cmax | ↔ | ↔ | 28%↑ | 51%↑ | ↔ | ↔ | ↔ | ↔ |
Ctau | ↔ | ↔ | NR | 74%↑ | NR | ↔ | ↔ | ↔ |
Note: The % change is presented in the table based on calculated %GLSM ratios; 90% CI of the GLSM ratios were within (), extended above (↑) the predefined lack of PK alteration boundaries of 70% to 143%. aAUClast presented for TAF. NR = not reported.