Abstract P187 – Table 1. Median changes in lipid profiles after switch from TDF to TAF, according to the third drug
| TDF | TAF | Δ | p | ||
|---|---|---|---|---|---|
| PI/c | Total cholesterol | 198 (184 to 219) | 209 (204 to 236) | +19 (+5 +37) | 0.02 |
| LDL | 122 (96 to 133) | 129 (115 to 152) | +15 (−9 +25) | 0.06 | |
| HDL | 47 (33 to 56) | 50 (42 to 66) | +7 (+1 +10) | 0.04 | |
| Triglycerides | 121 (90 to 187) | 134 (95 to 159) | +9 (−10 +15) | 0.6 | |
| INSTI/c | Total cholesterol | 181 (163 to 201) | 209 (182 to 228) | +26 (+8 +40) | <0.0001 |
| LDL | 108 (93 to 126) | 124 (109 to 148) | +18 (+2 +30) | <0.0001 | |
| HDL | 46 (38 to 53) | 50 (40 to 59) | +4 (−1 +8) | <0.0001 | |
| Triglycerides | 117 (88 to 156) | 135 (94 to 186) | +12 (−10 +53) | 0.0009 | |
| INSTI | Total cholesterol | 162 (124 to 201) | 195 (153 to 217) | +34 (+19 +50) | 0.003 |
| LDL | 76 (56 to 115) | 100 (83 to 125) | +25 (+10 +32) | 0.04 | |
| HDL | 44 (38 to 51) | 51 (48 to 56) | +4 (+0 +18) | 0.1 | |
| Triglycerides | 82 (54 to 127) | 98 (83 to 139) | +21 (+7 +52) | 0.09 | |
| NNRTI | Total cholesterol | 167 (146 to 185) | 186 (165 to 204) | +19 (+6 +34) | <0.0001 |
| LDL | 99 (83 to 117) | 114 (95 to 131) | +14 (+0 +25) | <0.0001 | |
| HDL | 43 (37 to 50) | 49 (40 to 61) | +7 (+2 +14) | <0.0001 | |
| Triglycerides | 91 (74 to 127) | 111 (82 to 144) | +7 (−16 +41) | 0.04 |