Table 5.

Sensitivity analyses

	HR (95% CI) adjusted for maximal K&L at baseline	HR (95% CI) corrected for maximal K&L during follow-up
Joint Model with slope included for pain
Pain	1.08 (1.06–1.10)	1.07 (1.05–1.09)
Pain slope	225 (0–276 × 106)	2.46 (0–15 × 106)
Sexa	0.60 (0.34–1.05)	0.68 (0.39–1.20)
Age (years)	1.06 (1.01–1.10)	1.05 (1.01–1.10)
BMI	0.94 (0.89–0.99)	0.95 (0.90–1.00)
Maximal K&L score	2.93 (1.53–5.61)	1.85 (1.38–2.47)
Number of painful joints	0.73 (0.57–0.93)	0.76 (0.60–0.98)
Comorbidities	0.78 (0.67– 0.92)	0.79 (0.67–0.93)
Joint Model with slope included for function
Function	1.06 (1.05–1.08)	1.06 (1.04–1.07)
Function slope	1,801 (0–683 × 106)	33.5 (0–52 × 106)
Sexa	0.75 (0.43–1.30)	0.81 (0.46–1.40)
Age (years)	1.05 (1.01: 1.10)	1.05 (1.00: 1.10)
BMI	0.95 (0.90–1.00)	0.95 (0.90–1.00)
Maximal K&L score	2.95 (1.54–5.64)	1.85 (1.39–2.46)
Number of painful joints	0.73 (0.57–0.94)	0.78 (0.61–1.00)
Comorbidities	0.81 (0.69–0.94)	0.82 (0.71–0.96)

HR: hazard ratio.

K&L: Kellgren and Lawrence

^aMen as reference category