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. 2018 Oct 25;11:93. doi: 10.1186/s12920-018-0409-z

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Forest plot showing the proportion of VUSs among positive cases between prenatal studies and postnatal studies. The rectangles represent the VUS fraction in each study with 95% confidence interval bounds. The diamond in each group represents the combined proportion of VUSs with all studies included