Table 4.
Univariate analyses of the associations between FGFR polymorphisms and the response of neoadjuvant chemotherapy
| Target Gene | Polymorphisms/Genotype | Nonresponders N = 29(32%) |
Responders N = 61(68%) |
OR (95% CI) | P | P HWE |
|---|---|---|---|---|---|---|
| FGFR1 | rs2288696 | 0.014 | ||||
| C/C | 25(86.2) | 50(82.0) | Reference | 1.000 | ||
| C/T | 1(3.4) | 11(18.0) | 1.00 (0.28–3.64) | 0.999 | ||
| T/T | 3(10.3) | 0(0) | 0 | 0.615 | ||
| Dominat model | 4(13.8) | 4(6.6) | 0.73(0.21–2.52) | |||
| Recessive model | 26(89.7) | 61(100) | 0 | 1.000 | ||
| Alleles | ||||||
| C | 51(87.9) | 111(91.0) | Reference | 0.344 | ||
| T | 7(12.1) | 11(9.0) | 0.57(0.18–1.82) | 0.999 | ||
| FGFR2 | rs2981582 | 0.343 | ||||
| C/C | 11(37.9) | 31(50.8) | Reference | |||
| C/T | 15(51.7) | 21(34.4) | 2.01(0.78–5.23) | 0.151 | ||
| T/T | 3(10.3) | 9(14.8) | 0.94(0.22–4.11) | 0.934 | ||
| Dominat model | 18(62.1) | 30(49.2) | 1.69(0.69–4.17) | 0.254 | ||
| Recessive model | 26(89.7) | 52(85.2) | 1.50(0.37–6. 02) | 0.567 | ||
| Alleles | ||||||
| C | 37(63.8) | 83(68.0) | Reference | |||
| T | 21(36.2) | 39(32.0) | 1.21(0.63–2.33) | 0.573 | ||
| rs1219648 | 0.700 | |||||
| A/A | 9(31.0) | 19(31.1) | Reference | |||
| A/G | 16(55.2) | 30(49.2) | 1.13(0.42–3.06) | 0.816 | ||
| G/G | 4(13.8) | 12(19.7) | 0.70(0.18–2.80) | 0.618 | ||
| Dominat model | 20(69.0) | 42(68.9) | 1.01(0.39–2.61) | 0.99 | ||
| Recessive model | 25(86.2) | 49(80.3) | 1.53(0.45–5.24) | 0.498 | ||
| Alleles | ||||||
| A | 34(58.6) | 68(55.7) | Reference | |||
| G | 24(41.4) | 54(44.3) | 0.89(0.47–1.67) | 0.715 | ||
| rs2420946 | 0.377 | |||||
| T/T | 1(3.4) | 11(18.0) | Reference | |||
| C/T | 18(62.1) | 29(47.5) | 6.83(0.81–57.45) | 0.077 | ||
| C/C | 10(34.5) | 21(34.4) | 5.24(0.59–46.40) | 0.137 | ||
| Dominat model | 28(96.6) | 50(82.0) | 6.16(0.76–50.24) | 0.090 | ||
| Recessive model | 22(75.9) | 54(88.5) | 1.00 (0.39–2.53) | 0.996 | ||
| Alleles | ||||||
| T | 20(34.5) | 51(41.8) | Reference | |||
| C | 38(65.5) | 71(58.2) | 1.37(0.71–2.61) | 0.348 | ||
| rs2981579 | 0.060 | |||||
| T/T | 7(24.1) | 18(29.5) | Reference | |||
| C/T | 12(41.4) | 24(39.3) | 1.29(0.42–3.92) | 0.659 | ||
| C/C | 10(34.5) | 19(31.1) | 1.35(0.42–4.32) | 0.610 | ||
| Dominat model | 22(75.9) | 43(70.5) | 2.39(0.96–5.99) | 0.062 | ||
| Recessive model | 26(89.7) | 51() | 0.86(0.34–2.20) | 0.752 | ||
| Alleles | ||||||
| T | 26(44.8) | 60(49.2) | Reference | |||
| C | 32(55.2) | 62(50.8) | 1.19(0.64–2.23) | 0.585 | ||
| rs2981578 | 0.060 | |||||
| G/G | 10(34.5) | 34(55.7) | Reference | |||
| A/G | 12(41.4) | 20(32.8) | 2.04(0.75–5.57) | 0.164 | ||
| A/A | 7(24.1) | 7(11.5) | 3.40(0.96–12.02) | 0.058 | ||
| Dominat model | 19(65.5) | 27(44.3) | 2.39(0.96–5.99) | 0.062 | ||
| Recessive model | 22(75.9) | 54(88.5) | 0.41(0.13–1.30) | 0.129 | ||
| Alleles | ||||||
| G | 32(55.2) | 88(72.1) | Reference | |||
| A | 26(44.8) | 34(27.9) | 2.10(1.10–4.03) | 0.025* | ||
| FGFR3 | rs743682 | 0.198 | ||||
| G/G | 25(86.2) | 49(80.3) | Reference | |||
| A/G | 3(10.3) | 11(18.0) | 0.54(0.14–2.09) | 0.368 | ||
| A/A | 1(3.4) | 1(1.6) | 1.96(0.12–32.67) | 0.639 | ||
| Dominat model | 4(13.8) | 12(19.7) | 0.65(0.65–0.19) | 0.498 | ||
| Recessive model | 27(93.1) | 61(100) | 0.47(0.03–7.74) | 0.595 | ||
| Alleles | ||||||
| G | 53(91.4) | 109(89.3) | Reference | |||
| A | 5(8.6) | 13(10.7) | 0.79(0.27–2.34) | 0.671 | ||
| FGFR4 | rs1966265 | 0.343 | ||||
| G/G | 8(27.6) | 12(19.7) | Reference | |||
| A/G | 18(62.1) | 22(36.1) | 1.23(0.41–3.65) | 0.713 | ||
| A/A | 3(10.3) | 27(44.3) | 0.17(0.04–0.74) | 0.019* | ||
| Dominat model | 21(72.4) | 49(80.3) | 1.16(0.64–1.80) | 0.401 | ||
| Recessive model | 26(89.7) | 34(55.7) | 6.88(1.88–25.2) | 0.004* | ||
| Alleles | ||||||
| G | 34(58.6) | 46(37.7) | Reference | |||
| A | 24(41.4) | 76(62.3) | 0.43(0.23–0.81) | 0.009* |
OR odds ratio, 95% CI 95% confidence interval, * A P value < 0.05 was considered ststistically significant