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RTKs in the islet microenvironment. The mature murine islet is composed of insulin-secreting β-cells in the core of the islet (blue) and other endocrine hormone–secreting cells along the islet’s periphery (red). β-cells express multiple RTKs that influence their growth and development. The direct effect of RTK activation on insulin secretion has been demonstrated to date in select RTKs. β-cells regulate and are influenced by RTKs expressed on the islet vasculature.
