Figure 8.
Insulin secretion correlated with pulsatility but not [Ca2+]i levels. (A,B) Scatter plots of MH-induced differences in insulin secretion (x-axis) plotted against MH-induced differences in the (A) amplitude of oscillations or (B) mean [Ca2+]i level (y-axis) for islets from db/db mice. Each data point represents the secretion of a set of 30 islets paired with [Ca2+]i imaging data recorded simultaneously for each individual islet in 11 mM glucose for 30 min. These findings support the hypothesis that reducing excessive glycolytic activity restores glucose sensing and normal islet function.