Fig. 4.

The hypoxia-induced decrease in the activity of the Akt/mTOR signaling pathway was more pronounced in young BM-MSCs compared with aged BM-MSCs. a Representative western blots of p-Akt/Akt and p-mTOR/mTOR in young and aged BM-MSCs. Semiquantification of the protein expression levels of p-Akt (b) and p-mTOR (c) (n = 5, *p < 0.05). d Representative western blots of p-p70S6 K/p70S6 K, and p-S6/S6 in young and aged BM-MSCs. Semiquantification of the protein expression levels of p-p70S6 K/p70S6 K (e) and p-S6/S6 (f) (n = 5, *p < 0.05)