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. 2018 Oct 25;9:284. doi: 10.1186/s13287-018-1028-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — IGF-1 knockdown increased autophagy. a Representative immunofluorescence images of GFP-LC3 (green fluorescent) and DAPI (blue fluorescence) in the BM-MSCs of each group. b Quantification of autophagy is shown as the percentage of BM-MSCs with LC3 (n = 5, *p < 0.05). c Quantification of the average number of autophagic structures in the cytoplasm d Representative western blots of LC3-I/LC3-II, ATG12-5, Beclin-1, and P62in BM-MSCs subjected to H/SD with or without IGF-1 siRNA administration. Semiquantification of the protein expression levels of LC3-II (e), ATG12–5 (f), p62 (h), and Beclin-1(g) at the indicated time point (n = 5, *p < 0.05)