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. 2018 Oct 25;9:284. doi: 10.1186/s13287-018-1028-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — IGF-1 knockdown protects aged BM-MSCs by increasing autophagy. a Representative terminal deoxynucleotidyl transferase-mediated nick-end labeling (TUNEL) images of aged BM-MSCs treated with IGF-1 siRNA with or without autophagy inhibition via 3-methyladenine (3-MA) and Atg7 small interfering RNA (siRNA). b Representative terminal deoxynucleotidyl transferase-mediated nick-end labeling (TUNEL) images of aged BM-MSCs treated with IGF-1 siRNA with or without autophagy inhibition via 3-methyladenine (3-MA) and Atg7 small interfering RNA (siRNA) under normal and hypoxic conditions. c Quantification of apoptotic BM-MSCs under normal and hypoxic conditions. d Representative immunofluorescence images of GFP-LC3 (green fluorescent) and DAPI (blue fluorescence) in BM-MSCs of each group (scale bars, 20 mm). e Histogram showing the percentages of BM-MSCs with punctate LC3 in each group under normal and hypoxic conditions