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. 2018 Jul-Sep;36(3):345–352. doi: 10.1590/1984-0462/;2018;36;3;00003

Table 1: Health Maintenance Timeline for Children with Prader-Willi Syndrome.

Lab Follow-up/Intervention Timing Recommendations
IGF-1 IGFBP3 At 3 months and after starting rhGH every 4-6 months Maintain levels between +1 and +2 SD of IGF-1 during GH use
TSH Free T4 Every 12 months With abnormal levels, conduct stricter follow-up
Glucose profile (glucose, Insulin) Every 4-6 months Consider metformin in females. Consider Hb1Ac and OGTT if insulin resistance
ACTH and cortisol levels Before starting rhGH therapy and in other situations of severe comorbidity All patients are advised to use corticosteroids for stressful conditions (during surgery or systemic disease):
Attack with 50 mg/m2 of hydrocortisone
Maintenance: 100 mg/m2 /day of hydrocortisone
Cholesterol and triglycerides Every 6-12 months Depending on weight, levels and diet
Polysomnography Every 6-12 months Also, with abnormal weight gain, snoring, appearance of daytime symptoms or poor school performance
Orthopedic Evaluation Once a year Check for scoliosis
Dental Check-Up Every 6 months Start teaching tooth care at a young age. Teeth should be washed twice a day, beginning as soon as the first tooth appear.