Fig. 4.

Event history of all autoimmune thrombotic thrombocytopenic purpura (iTTP) patients with detailed therapy data. Acute iTTP episodes of all 70 patients from the first day of first acute thrombotic thrombocytopenic purpura (TTP) episode until end of observation time in days. Patients were pseudonymized with a number code. Men are listed (above dotted horizontal line no. 19–156) in the upper part and women in the lower part of the figure (below dotted line no. 2–155). Acute iTTP episodes are represented by a black dot. If being treated by rituximab, this circle is bordered by red rectangles. Empty circles represent the last day of observation. Two patients died during a relapse (Died): including one woman following her first acute TTP relapse (no. 82). She had denied plasma products for religious beliefs. One man did not survive his 13th acute TTP episode (no. 44).