Table 2.

Comparison of each of the patient-reported outcomes and physiological measurement during the recovery phase from acute exacerbation of COPD

Patient-reported outcomes	Day 1		Day 7		Day 14		Day 21		Day 28		Day 56			Day 84
	n		n		n		n		n		n		n
Patient-reported outcomes
EXACT total score	33	50.5±12.4	32	37.0±11.6	31	32.5±14.3	32	35.0±16.2	33	33.4±14.9	30	33.1±14.6	27	33.4±16.0
Breathlessness domain score	33	54.7±24.9	33	34.4±19.4	32	28.3±25.4	32	36.1±26.0	33	33.0±25.0	30	32.9±23.8	27	35.6±26.4
Cough and sputum domain score	33	38.8±21.8	33	26.1±13.9	32	17.2±13.7	32	19.5±14.6	33	19.0±19.2	30	18.4±16.5	27	19.0±15.7
Chest symptoms domain score	33	48.0±20.0	33	27.5±17.2	32	19.4±18.8	32	26.7±20.7	33	21.6±21.0	30	19.8±20.4	27	22.3±21.3
CAT score	33	24.4±8.5	33	16.2±7.3	32	13.5±8.4	32	13.9±8.1	33	13.3±8.4	30	13.7±8.3	27	13.3±8.6
SGRQ total score	31	55.1±19.8	33	49.3±22.4	32	41.8±25.3	31	44.3±23.9	32	42.1±23.3	29	40.3±23.6	26	40.6±25.5
SGRQ symptoms	31	66.7±20.8	33	68.9±17.4	32	63.2±20.7	32	63.5±21.4	32	61.8±23.6	30	56.7±20.1	27	52.4±25.5
SGRQ activity	31	67.7±25.9	33	58.7±28.7	32	51.2±32.5	31	56.5±31.0	32	54.2±30.9	29	51.7±30.9	26	54.8±33.2
SGRQ impact	31	44.2±22.2	33	37.9±24.2	32	29.9±26.4	32	30.0±24.6	33	28.0±22.6	30	29.7±23.3	27	27.3±25.2
Hyland Scale score	31	42.6±20.7	32	59.7±21.2	32	63.8±21.0	30	61.5±21.1	31	61.0±21.6	27	59.8±17.6	26	61.3±20.8
D-12 total score	30	10.3±9.7	30	5.3±5.5	32	3.8±5.3	31	4.6±6.0	32	4.3±5.7	30	3.4±6.0	26	3.8±6.4
D-12 physical score	30	7.3±5.9	32	4.3±3.8	32	2.8±3.6	31	3.4±4.0	32	3.1±3.7	30	2.4±3.6	26	2.8±4.1
D-12 affective score	31	3.2±4.1	31	1.2±2.2	32	1.0±1.9	31	1.3±2.4	32	1.1±2.2	30	1.0±2.6	27	1.0±2.4
Spirometry
FVC (L)	31	2.17±0.68	－	－	33	2.45±0.61	－	－	33	2.45±0.64	32	2.46±0.65	30	2.46±0.67
FVC (%predicted)	31	71.6±22.8	－	－	33	81.0±20.1	－	－	33	81.6±22.7	32	83.0±23.4	30	81.0±22.3
FEV1 (L)	31	1.02±0.50	－	－	33	1.22±0.53	－	－	33	1.20±0.53	32	1.19±0.55	30	1.22±0.56
FEV1 (%predicted)	31	42.7±19.1	－	－	33	51.6±20.7	－	－	33	51.3±22.2	32	51.6±23.8	30	51.3±22.9
Arterial blood gas*
PaO2 (mm Hg)	32	67.5±11.4	－	－	33	75.6±12.3	－	－	33	76.7±14.4	33	75.9±11.1	30	73.4±13.4
PaCO2 (mm Hg)	32	42.0±12.1	－	－	33	43.1±8.2	－	－	33	42.7±7.9	33	42.2±7.8	30	43.7±8.0
pH	32	7.408±0.048	－	－	33	7.397±0.030	－	－	33	7.395±0.032	33	7.401±0.031	30	7.388±0.030

*Oxygen was administered to six subjects; one subject received non-invasive positive pressure ventilation. Data are presented as mean±SD.

CAT, COPD Assessment Test; COPD, chronic obstructive pulmonary disease; D-12, Dyspnoea-12; EXACT, Exacerbations of Chronic Pulmonary Disease Tool; FEV₁, forced expiratory volume in 1 s; FVC, forced vital capacity; PaCO₂, arterial carbon dioxide pressure; PaO₂, arterial oxygen pressure; SGRQ, St George’s Respiratory Questionnaire.