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. 2018 Oct 18;11:7187–7196. doi: 10.2147/OTT.S180962

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© 2018 Su et al. This work is published and licensed by Dove Medical Press Limited

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Effect of SPHK1 knockdown by siRNA in terms of STAT3 expression in SH-SY5Y cells and tumor tissues of nude mice.

Notes: (A) STAT3 mRNA level was significantly reduced in SH-SY5Y cells and tumor tissues of nude mice with SPHK1 knockdown compared with the negative control or blank control. (B) STAT3 protein level was lower in SH-SY5Y cells and tumor tissues of nude mice with SPHK1 knockdown than that in the negative control or blank control group. **P<0.01 vs negative control or blank control groups.

Abbreviation: SPHK1, sphingosine kinase 1.