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. 2018 Oct 8;53(6):2409–2422. doi: 10.3892/ijo.2018.4586

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Mst1 is downregulated in A549 cells and regulates A549 cell apoptosis. (A and B) Western blotting was used to analyze the protein expression levels of Mst1 in the normal pulmonary epithelial cell line BEAS-2B and in A549 cells. (C) Immunofluorescence analysis of Mst1; DAPI used to label the nuclei. (D and E) Mst1 overexpression was performed via Ad-Mst1 transduction. Western blotting was used to evaluate the protein expression levels of Mst1 in response to Ad-Mst1 transduction. (F) MTT assay was used to analyze cell viability following Ad-Mst1 transduction. (G and H) TUNEL assay was used to quantify the cellular apoptotic rate. The number of TUNEL-positive cells was recorded. ^*P<0.05. Ad, adenovirus; Mst1, mammalian STE20-like kinase 1; TUNEL, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling.