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Mst1 overexpression promoted mitochondrial injury, as evidenced by reduced mitochondrial potential, uncontrolled oxidative stress, increased pro-apoptotic protein translocation, reduced mitochondrial energy metabolism and activated caspase-9 signals. Furthermore, Mst1 overexpression impaired migration and reduced proliferation in A549 cells. Mst1, mammalian STE20-like kinase 1; ROCK1, Rho-associated coiled-coil containing protein kinase 1.
