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. 2018 Sep 21;53(6):2531–2541. doi: 10.3892/ijo.2018.4569

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Schematic diagram indicating how curcumin exerts anticancer effects on RN5 murine mesothelioma cells. Curcumin suppressed PI3K-Akt-mTOR signaling pathway by downregulating PI3K, p-Akt, p-mTOR and p-p70S6K and induced apoptosis through mitochondrial, caspase-independent and AIF-dependent pathways. AIF, apoptosis-inducing factor; Akt, AKT serine/threonine kinase; Bax, B-cell lymphoma-2-associ-ated X protein; Bcl-xL, B-cell lymphoma-extra large; mTOR, mammalian target of rapamycin; p, phosphorylated; P70S6k, p70 ribosomal protein S6 kinase; PI3K, phosphoinositide 3-kinase.