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. 2018 Sep 12;53(6):2369–2378. doi: 10.3892/ijo.2018.4558

Figure 5.

Figure 5

Knockdown of CPNE1 inhibits tumor growth in vivo. (A) CPNE1-silenced A549 cell xenografts in nude mice (n=6) at the experimental endpoint; tumors were dissected and images were captured as presented. (B) Tumor growth curves in mice (n=6 in each group) inoculated with the indicated cells at the indicated days. (C) Each tumor formed was weighed and the mean weight in each group was calculated. (D) Immunohistochemical staining for CPNE1 was quantified based on staining intensity. *P<0.05 and **P<0.01 vs. sh-NC. CPNE1, Copine 1; sh-NC, negative control cells; sh-CPNE1, CPNE1-silenced cells; HE, hematoxylin and eosin.