Table I.
Variable | Total no. of patients, n=120 (%) | miR-103
|
P-value | LATS2
|
P-value | ||
---|---|---|---|---|---|---|---|
Low expression | High expression | Low expression | High expression | ||||
Age (years) | 0.057 | 0.120 | |||||
<50 | 49 (40.8) | 10 | 39 | 37 | 12 | ||
≥50 | 71 (59.2) | 26 | 45 | 44 | 27 | ||
Sex | 0.496 | 0.349 | |||||
Female | 21 (17.5) | 5 | 16 | 16 | 5 | ||
Male | 99 (82.5) | 31 | 68 | 65 | 34 | ||
HBsAg | 0.955 | 0.903 | |||||
Positive | 76 (63.3) | 15 | 61 | 51 | 25 | ||
Negative | 44 (36.7) | 21 | 23 | 30 | 14 | ||
AFP (ng/ml) | 0.01a | 0.422 | |||||
<400 | 97 (80.8) | 24 | 73 | 50 | 27 | ||
≥400 | 23 (19.2) | 12 | 11 | 31 | 12 | ||
Cirrhosis | 0.741 | 0. 903 | |||||
Yes | 76 (63.3) | 22 | 54 | 51 | 25 | ||
No | 44 (36.7) | 14 | 30 | 30 | 14 | ||
Tumor size (cm) | 0.007a | 0.032a | |||||
<5 | 48 (40) | 21 | 27 | 27 | 21 | ||
≥5 | 72 (60) | 15 | 57 | 54 | 18 | ||
Tumor multiplicity | 0.228 | 0.992 | |||||
Single | 77 (64.2) | 26 | 51 | 52 | 25 | ||
Multiple | 43 (35.8) | 10 | 33 | 29 | 14 | ||
Differentiation | 0.318 | 0.383 | |||||
Well-moderate | 53 (44.2) | 17 | 36 | 38 | 15 | ||
Poor-undifferentiated | 67 (55.8) | 19 | 48 | 43 | 24 | ||
Microscopic vascular invasion | <0.001b | 0.001a | |||||
Yes | 39 (32.5) | 28 | 11 | 18 | 21 | ||
No | 81 (67.5) | 8 | 73 | 63 | 18 | ||
Stage | <0.001b | 0.021a | |||||
I–II | 78 (65) | 32 | 46 | 47 | 31 | ||
III–IV (with metastasis) | 42 (35) | 4 | 38 | 34 | 8 |
Values in bold indicate statistical significance (aP<0.05 and bP<0.01).