Table 1.

Characteristics of the included studies

Study	Year	Study location	Treatments
			Treatment 1	Age (years)	Cases/n	Treatment 2	Age (years)	Cases/n	Treatment 3	Age (years)	Cases/n
Andersen et al7	1989	France	Fluconazole	32.1	143/169	Clotrimazole	30.6	131/161
Corić et al8	2006	Croatia	Fluconazole	NA	41/56	Clotrimazole	NA	9/13
Costa et al9	2004	Brazil	Fluconazole	NA	30/38	Itraconazole	NA	27/42
de Punzio et al10	2003	Italy	Fluconazole	>18.0	29/38	Itraconazole	>18.0	21/32
Fan et al11	2015	China	Fluconazole	19.0–45.0	241/287	Miconazole	19.0–45.0	220/290
Ferahbas et al12	2006	Turkey	Fluconazole	17.0–54.0	10/15	Itraconazole	17.0–54.0	6/10	Terbinafine	17.0–54.0	4/12
Li et al13	2015	China	Fluconazole	29.6	46/58	Terconazole	31.0	47/66
McClelland et al14	2015	USA	Miconazole	24.0–34.0	75/118	Placebo	23.0–35.0	30/116
Mendling et al15	2004	Germany	Fluconazole	NA	129/161	Clotrimazole	NA	117/154
Mikamo et al16	1995	Japan	Fluconazole	18.0–54.0	38/50	Clotrimazole	18.0–54.0	30/50
Mikamo et al5	1998	Japan	Fluconazole	18.0–55.0	40/50	Itraconazole	17.0–55.0	42/50	Clotrimazole	21.0–54.0	36/50
O-Prasertsawat and Bourlert17	1995	China	Fluconazole	33.9±8.1	42/53	Clotrimazole	35.3±8.4	40/50
Osser et al18	1991	Sweden	Fluconazole	16.0–52.0	100/121	Econazole	18.0–60.0	84/114
Seidman and Skokos19	2005	USA	Fluconazole	37.0±12.2	76/93	Butoconazole	38.8±13.8	56/88
Sekhavat et al20	2011	Iran	Fluconazole	39.4±13.1	60/72	Clotrimazole	42.2±15.9	49/70
Sobel et al21	1995	USA	Fluconazole	18.0–63.0	133/182	Clotrimazole	17.0–64.0	118/176
Sobel et al22	2004	USA	Fluconazole	NA	160/166	Placebo	NA	23/154
Stein et al23	1991	USA	Fluconazole	18.0–51.0	80/90	Clotrimazole	18.0–60.0	88/95
Stein and Mummaw24	1993	USA	Itraconazole	18.0–43.0	35/48	Clotrimazole	18.0–33.0	19/20	Placebo	18.0–39.0	7/22
Timonen25	1992	Finland	Fluconazole	>18.0	50/54	Miconazole	>18.0	33/47
Tobin et al26	1992	UK	Itraconazole	>18.0	60/92	Clotrimazole	>18.0	49/88
van Heusden et al27	1990	Netherlands	Fluconazole	NA	47/49	Miconazole	NA	48/50
Zhou et al28	2016	China	Fluconazole	29.9±6.5	61/110	Clotrimazole	29.4±6.2	62/115
Sobel et al42	1994	USA	Ketoconazole	>18.0	86/101	Clotrimazole	>18.0	41/51
Fong29	1992	Canada	Itraconazole	18.0–65.0	17/22	Clotrimazole	18.0–65.0	21/22
Gerhard et al43	1989	USA	Ketoconazole	>18.0	27/45	Placebo	>18.0	21/47
Kutzer et al46	1988	UK	Fluconazole	17.0–65.0	63/80	Ketoconazole	17.0–72.0	55/72
Sobel44	1986	USA	Ketoconazole	31.9	15/21	Placebo	31.9	6/21
van der Meijden et al45	1986	Netherlands	Ketoconazole	29.0±6.9	20/23	Miconazole	28.0±7.4	18/19
Kjaeldgaard58	1986	USA	Terconazole	>18.0	18/20	Clotrimazole	>18.0	17/20
Puolakka and Tuimala30	1983	Finland	Ketoconazole	16.0–46.0	40/49	Miconazole	18.0–47.0	34/49
Corson et al31	1991	USA	Terconazole	18.0–54.0	250/299	Miconazole	18.0–54.0	239/294
Thomason et al32	1990	USA	Terconazole	NA	40/50	Miconazole	NA	34/50	Placebo	NA	7/49
Brown et al39	1999	USA	Butoconazole	18.0–65.0	93/101	Miconazole	18.0–65.0	90/104
Ruf and Vitse40	1990	France	Butoconazole	18.0–56.0	26/29	Econazole	16.0–49.0	24/32
Kaufman et al37	1989	USA	Butoconazole	>18.0	101/115	Miconazole	>18.0	93/114
Hajman38	1988	Sweden	Butoconazole	20.0–63.0	28/32	Clotrimazole	19.0–32.0	24/31
Brown et al33	1986	USA	Butoconazole	>18.0	26/32	Miconazole	>18.0	21/30	Placebo	>18.0	2/29
Adamson et al34	1986	USA	Butoconazole	NA	92/97	Clotrimazole	NA	74/88
Stettendorf et al35	1982	USA	Clotrimazole	16.0–62.0	45/54	Econazole	16.0–66.0	41/57
Perera and Seneviratne36	1994	Sri Lanka	Econazole	NA	49/51	Clotrimazole	NA	45/50