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. 2018 Oct;59(12):5127–5139. doi: 10.1167/iovs.18-25046

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Copyright 2018 The Authors

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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ERG responses of B6.Cg-Crb1^rd8Jak3^m1J/Boc and C57BL/6J at 8 weeks and 8 months of age. Scotopic responses were recorded after an overnight dark-adaptation, while light-adapted responses were recorded with a background light of 1.46 log cd/m² following a 10-minute exposure of the same range of stimulus intensities (see “Methods”). A reduction in scotopic ERG response is observed at 8 weeks in B6.Cg-Crb1^rd8Jak3^m1J/Boc mutants compared to controls, and in 8 week old compared to 8-month-old B6.Cg-Crb1^rd8Jak3^m1J/Boc mutants. Both scotopic and photopic responses were reduced in 8 month old mutants compared to 8-week-old mutants.