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. 2018 Oct;59(12):5127–5139. doi: 10.1167/iovs.18-25046

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Copyright 2018 The Authors

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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Genetic and molecular analysis of the rnv3 strain. (A) A total of 120 progeny from a rnv3/rnv3 X (rnv3/DBA/2J) F1 mice backcross were genotyped. Linkage to several markers on mouse Chr 1 was observed. The columns of squares represent haplotypes (filled boxes, rnv3/rnv3 allele; open boxes, rnv3/DBA/2J allele). The number of chromosomes associated with each haplotype is indicated below each column. (B) Genetic map of Chr 1 in the rnv3 region showing the closest markers and the region of human homology. (C) Integrative genomics viewer (IGV) shows the deleted base. (D) A total of 48 progeny from a m1J/m1J x (m1J/DBA/2J) F1 mice backcross were genotyped. Linkage to several markers on mouse Chr 8 was observed. The columns of squares represent haplotypes (filled boxes, m1J3/m1J allele; open boxes, m1J/DBA/2J allele). The number of chromosomes associated with each haplotype is indicated below each column. (E) Genetic map of Chr 8 in the m1J region showing the closest markers and the region of human homology. (F) IGV shows the base substitution.