Fig. 1.

FBXO17 is highly expressed in a subset of lung cancer cell lines and primary lung bronchogenic tumors. a Cell lysates of lung cancer cell lines were immunoblotted for FBXO17 protein expression with β-actin as a loading control. b Normal lung tissue and A549 lysates were immunoblotted for FBXO17 protein with β-actin as a loading control. c FBXO17 gene expression amplification was observed in a subset of lung squamous cell carcinoma and adenocarcinoma cases. The results presented here are in whole or part based upon data generated from the Cancer Genome Atlas Network: http://cancergenome.nih.gov/ (n = 1144 samples). d RNA-sequencing of resected non-small cell lung cancer tumor is displayed in a t-distributed stochastic neighbor embedding (tSNE) plot showing RNA expression of cell-specific markers including epithelial adhesion molecule (EPCAM, epithelial cells), protein tyrosine phosphatase receptor type C (PTPRC, leukocytes), and secretoglobin family 1A member 1 (SCGB1A1, club cells)