Table 3.
LV and RV Functional Parameters Compared by Patient Age for T0, T1, and T2a
| Parameter | T0 | T1 | T2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| < 50 y (n = 30) |
50-59 y (n = 25) |
≥60 y (n = 11) |
P Value | < 50 y (n = 30) |
50-59 y (n = 25) |
≥60 y (n = 11) |
P Value | < 50 y (n = 30) |
50-59 y (n = 25) |
≥60 y (n = 11) |
P Value | |
| EF, % | 64.16 (4.14) |
65.56 (4.65) |
66.50 (4.75) |
.17 | 61.53 (4.51) |
61.70 (5.68) |
61.38 (10.93) |
.99 | 59.81 (3.73) |
60.19 (6.44) |
60.80 (5.54) |
.052 |
| LV longitudinal | ||||||||||||
| S, % | −18.34 (2.85) |
−17.69 (2.86) |
− 17.31 (2.34) |
.39 | −16.82 (2.74) |
− 14.35 (2.79)b |
− 14.77 (2.53)b |
.007 | − 17.03 (3.27) |
− 15.33 (2.71)b |
−15.06 (2.79)b | .009 |
| SRs, l/s | −1.05 (0.17) | −1.08 (0.18) |
− 1.03 (0.15) |
.58 | − 1.09 (0.19) |
−0.97 (0.22) |
−1.00 (0.25) |
.12 | −1.03 (0.16) |
−0.99 (0.18) |
− 0.92 (0.19) |
.22 |
| SRe, l/s | 1.16 (0.29) |
1.06 (0.26) |
1.02 (0.22) |
.14 | 1.11 (0.25) |
1.00 (0.28) |
1.04 (0.37) |
.35 | 1.13 (0.29) |
1.00 (0.22) |
0.84 (0.26)b |
.009 |
| LV circumferential | ||||||||||||
| S, % | −23.02 (3.48) |
−22.81 (4.58) |
−24.13 (5.21) |
.56 | −21.52 (3.76) |
−20.47 (3.53) |
− 22.02 (4.47) |
.40 | − 20.21 (4.31) |
−19.71 (4.88) |
− 23.26 (3.66) | .08 |
| SRs, l/s | −1.51 (0.28) |
−1.73 (0.36) |
− 1.61 (0.52) |
.11 | − 1.42 (0.26) |
−1.36 (0.30) |
− 1.41 (0.38) |
.05 | − 1.32 (0.32) |
−1.34 (0.35) |
− 1.54 (0.45) |
.20 |
| SRe, l/s | 1.57 (0.34) |
1.75 (0.54) |
1.50 (0.51) |
.18 | 1.46 (0.40) |
1.49 (0.35) |
1.49 (0.47) |
.96 | 1.34 (0.32) |
1.39 (0.43) |
1.53 (0.56) |
.43 |
| LV radial | ||||||||||||
| S, % | 41.52 (12.58) |
35.09 (13.13) |
38.83 (11.18) |
.16 | 37.73 (13.92) |
38.65 (10.35) |
37.32 (13.53) |
.90 | 38.13 (13.09) |
35.58 (12.55) |
35.91 (11.51) |
.74 |
| SRs, l/s | 2.41 (0.82) |
2.82 (2.67) |
2.29 (0.76) |
.52 | 2.08 (0.62) |
2.33 (0.63) |
2.24 (0.78) |
.38 | 2.03 (0.69) |
2.15 (0.95) |
1.82 (0.64) |
.51 |
| SRe, l/s | −2.53 (1.12) |
−2.31 (0.85) |
−2.14 (1.05) |
.41 | − 2.10 (0.69) |
− 2.41 (0.99) |
−2.24 (1.00) |
.45 | −2.18 (0.93) |
− 2.25 (1.12) |
−1.92 (0.95) |
.66 |
| RV longitudinal | ||||||||||||
| S, % | −23.95 (7.82) |
−22.14 (3.95) |
− 20.61 (3.25) |
.31 | −18.87 (5.86) |
− 16.85 (4.74) |
− 16.54 (5.15) |
.36 | − 19.54 (5.22) |
− 18.37 (5.47) |
− 17.96 (4.24) | .58 |
| SRs, l/s | −1.42 (0.38) |
− 1.44 (0.34) |
− 1.31 (0.16) |
.61 | − 1.24 (0.28) |
−1.20 (0.26) |
− 1.21 (0.32) |
.89 | − 1.35 (0.35) |
−1.19 (0.37) |
− 1.25 (0.21) |
.22 |
| SRe, l/s | 1.53 (0.39) |
1.51 (0.40) |
1.27 (0.37) |
.056 | 1.37 (0.37) |
1.21 (0.36) |
0.96 (0.38)b |
.04 | 1.30 (0.43) |
1.21 (0.40) |
1.29 (0.43) |
.75 |
Abbreviations: EF ejection fraction, LV left ventricular, RV right ventricular, S strain, SRe peak early diastolic strain rate, SRs peak systolic strain rate, T0 baseline (pretreatment), T1 time from start of chemotherapy to first echocardiogram, T2 time from start of chemotherapy to second echocardiogram. (SD)
aData are expressed as mean (±SD)
bP < .05 vs age < 50 years