Fig. 2.

Permanent histopathology specimen of submandibular gland lesion (A) shows large regular islands of carcinoid tumor cells in a so-called organoid pattern on the right, with residual submandibular acini and ducts on the left (Hematoxylin & eosin staining; original magnification ×100). (B) On higher (×400) magnification, features characteristic of neuroendocrine tumor cells are apparent with hematoxylin & eosin staining showing cells with a characteristic coarsely granular “salt-and-pepper” chromatin. (C) Positive chromogranin immunostaining is consistent with neuroendocrine tumor cells.