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. 2018 Oct 26;13(10):e0205071. doi: 10.1371/journal.pone.0205071

Fig 2. IgG antibody responses specific for F and G protein antigens, and RSV neutralizing titers in prime immune sera.

Fig 2

RSV F and G protein specific IgG antibodies were determined by ELISA in sera collected at 3 weeks after prime immunization of mice (n = 5). (A) F protein specific IgG antibodies (μg/ml). (B) IgG antibodies (μg/ml) specific for G130-230 fragment. (C) RSV neutralizing antibody titers. RSV neutralizing antibody titers were determined by 50% plaque forming reduction (IC50%) assay. The linear line represents a lower limit of detection in RSV neutralizing titers. Results are presented as mean ± SEM (n = 5) and representative of duplicate experiments. Live RSV: the group of mice that were intranasally inoculated with RSV A2 (1x104 PFU/50 μl) as a live RSV control. Other groups are the same as described in the legend Fig 1. Statistical significances were performed by one-way ANOVA and Tukey’s multiple-comparison tests in GraphPad Prism or student T-test; ***p<0.0001, **p<0.001, *p<0.05.