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. 2018 Oct 25;13:53. doi: 10.1186/s13020-018-0211-z

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Clustering analysis of serum (a, b, c) and urine (d, e, f) metabolomic profiles. OPLS-DA models were built in patients with Liver Qi Stagnation (LQS) and Heart and Spleen Deficiency (HSD) subtypes of MDD and healthy controls (HC). Acceptable criteria for the models were defined as all R²X, R²Y, and Q² values of ≥ 0.5. Comparisons were conducted between HC and LQS (a, d), HC and HSD (b, e), and LQS and HSD (c, f)