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. 2018 Oct 25;13:53. doi: 10.1186/s13020-018-0211-z

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Biochemical pathway analysis shows biological impacts in differentiating Liver Qi Stagnation (LQS, a) and Heart and Spleen Deficiency (HSD, b) subtypes of MDD from healthy controls. X- and Y-axis indicates the magnitude of the impact and p value compared with healthy controls, respectively. Aminoacyl-tRNA biosynthesis and valine, leucine and isoleucine biosynthesis pathways are most closely associated with the two subtypes. The HSD subtype was additionally associated with valine, leucine and isoleucine degradation