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. 2018 Oct 26;19:177. doi: 10.1186/s13059-018-1534-x

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License(http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — On-target modulation frequency distribution of gRNAs that are binned into low, medium, and high specificity groups using CRISPRspec method. Distributions are given as kernel density estimates (filled curves) together with the cumulative distribution function (dashed lines) of on-target modulation frequencies for each specificity group, separately for each dataset. Given modulation frequencies represents the cleavage efficiency of the intended on-target and are dataset specific. Triangles on the x-axis indicates the median values