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. Author manuscript; available in PMC: 2018 Oct 26.
Published in final edited form as: Prostaglandins Leukot Essent Fatty Acids. 2017 Jan 11;136:161–169. doi: 10.1016/j.plefa.2017.01.002

Fig. 6.

Fig. 6.

Temporal comparison of the relative contributions of different triacylglycerol biosynthesis pathways to fat pools in liver and muscle between ob/ ob mice vs. their controls. Comprehensive cellular lipidomes of mouse organs were determined by MDMSSL as described in MATERIALS AND METHODS. The contributions of different triacylglycerol (TAG) biosynthesis pathways to TAG pools in mouse liver (Panel A) and thigh skeletal muscle (Panel B) of ob/ ob mice (solid bars) and their controls (open bars) at 10, 12, and 16 weeks of age were simulated using lipidomics data as previously described in detail [46]. These pathways represent the diacylglycerol generation, including phosphatidic acid dephosphorylation (K1), monoacylglycerol reacylation (K2), and hydrolysis of phospholipid head groups (K3). It was found that the pathway K3 was negligible in the current study. Thus, K1+ K2=1.