Table 1.
Clinical and laboratory features of the patients used as a source of human aβ2GPI antibodies (Pt1 - Pt7) and patients that received HCQ treatment (Pt 8 - Pt12). Pt indicates patient. All patients met Sidney Laboratory criteria for APS [28]. ACA= anticardiolipin, β2=β2gycoprotein I (β2GPI), RM=recurrent miscarriages, APS= primary antiphospholipid syndrome, DVT=deep vein thrombosis, PE= pulmonary embolism.
| Sex/age | ACA-IgG | β2GPI-IgG | LA | diagnostic | Clinical features | Obstetric APS | |
|---|---|---|---|---|---|---|---|
| Pt 1 | F/52 | + | + | + | PAPS | arterial thrombosis | RM Stillbirth |
| Pt 2 | M/62 | + | + | + | PAPS | DVT, stroke | |
| Pt 3 | F/48 | + | + | + | PAPS | DVT, PE | Preeclampsia |
| Pt 4 | F/38 | + | + | + | PAPS | DVT | RM preeclampsia |
| Pt 5 | M/54 | + | + | + | PAPS | arterial and venous thrombosis | |
| Pt 6 | F/54 | + | + | + | PAPS | DVT | RM, preterm birth, stillbirth |
| Pt 7 | F/45 | + | + | + | PAPS | RM, preeclampsia | |
| Pt 8 | F/38 | + | + | + | PAPS | RM Stillbirth | |
| Pt 9 | F/31 | + | + | + | PAPS | DVT | RM IUGR |
| Pt 10 | F/34 | + | + | + | PAPS | Preeclampsia HELLP syndrome | |
| Pt 11 | F/32 | + | + | + | PAPS | RM preeclampsia | |
| Pt 12 | F/34 | + | + | + | PAPS | venous thrombosis | RM, preeclampsia |