Table 4.
Ex-vivo gamma counting showing the biodistribution of NHIgG and aβ2GPI in pregnant and nonpregnant mice. Results are expressed as amount of IgG per g of tissue (ng IgG/ g of tissue) N=4-5 mice/group. * different from NHIgG, p<0.05, # different from pregnant mice, p<0.05
Pregnant | Non pregnant | ||||
---|---|---|---|---|---|
In111-conjugated IgG (ng IgG/g tissue) | aβ2GPI | aβ2GPI+HCQ | NHIgG | aβ2GPI | NHIgG |
Blood | 89±27* | 98±22* | 304±42 | 261±110# | 178±103# |
Placenta | 500±245 | 490±154 | 615±312 | ||
Fetal brain | 397±71* | 427±60* | 113±98 | ||
Spleen | 273±56 | 285±90 | 226±54 | 809±180# | 572±167# |
Liver | 192±91 | 178±105 | 154±43 | 521±163# | 372±65# |