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HCQ inhibits complement activation in vivo.
Complement split products C3adesArg and C5adesArg in serum from NHIgG-treated mice, APS-mice and APS-mice treated with HCQ. N=5-6 mice/experimental group. *Different from NHIgG, p<0.05
| C3a (ng/ml) | C5a (ng/ml) | |
|---|---|---|
| NHIgG | 43±7 | 21±5 |
| APS | 156±34* | 142±31* |
| APS + HCQ | 57±21 | 35±11 |
| HCQ | 39±9 | 18±7 |
