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. Author manuscript; available in PMC: 2018 Oct 26.
Published in final edited form as: Curr Opin Chem Eng. 2016 Sep 4;13:109–118. doi: 10.1016/j.coche.2016.08.016

Figure 3.

Figure 3

Examples of PNP biosensors and biocatalyst. a) The E2 PNP has the ability to be decorated with multiple sensing and output domains allowing it to be an efficient biosensor against a number of targets. Reprinted with permission from Sun Q, Chen Q, Blackstock D, Chen W: Post-Translational Modification of Bionanoparticles as a Modular Platform for Biosensor Assembly. ACS Nano 2015, 9:8554–8561. Copyright 2015, American Chemical Society. b) A three enzyme synthetic metabolon was incorporated into the P22 VLP to create a more efficient bioreactor. The three enzymes and shell protein were co-expressed and allowed to self-assemble into a nanobioreactor. Reprinted with permission from Patterson DP, Schwarz B, Waters RS, Gedeon T, Douglas T: Encapsulation of an enzyme cascade within the bacteriophage P22 virus-like particle. ACS Chem Biol 2014, 9:359–365. Copyright 2014, American Chemical Society.