Appendix 1—table 3. Meta-analysis of the UKBB and Helsinki cohorts.
All the genome-wide significant, LD-independent (r2 ≤0.3) associations from the meta-analysis stage. Seven SNPs were LD-independent when compared to the discovery stage SNPs, and rs117245733 is shown for reference. The numbers for regression coefficients (Beta), standard error of beta (SE) and association (P) were collected from the UKBB and Helsinki summary statistics and their fixed effect model meta-analysis. The bolded SNP was the only one to reach a suggestive association (p<10−5) in both cohorts.
| UKBB cohort | Helsinki cohort | Meta-analysis (fixed eff.) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs-code | Chr | Position | A | B | r2 (reference SNP) |
Beta | SE | P | Beta | SE | P | Beta | SE | P |
| rs17631680 | 2 | 67090367 | T | C | NA | 0.004 | 0.0007 | 2.1E-07 | 0.005 | 0.0029 | 6.2E-02 | 0.004 | 0.0007 | 4.29E-08 |
| rs1735537 | 3 | 128122820 | T | C | NA | −0.003 | 0.0005 | 1.2E-07 | −0.004 | 0.0021 | 8.7E-02 | −0.003 | 0.0005 | 3.01E-08 |
| rs67751869 | 4 | 54568834 | T | C | 0.14 (rs62323680) | −0.005 | 0.0009 | 9.9E-08 | −0.011 | 0.0039 | 3.7E-03 | −0.005 | 0.0009 | 5.05E-09 |
| rs6901631 | 6 | 152567047 | T | C | 0.26 (rs6904757) | 0.003 | 0.0006 | 5.4E-08 | 0.005 | 0.0031 | 1.2E-01 | 0.003 | 0.0006 | 1.76E-08 |
| rs11790408 | 9 | 876418 | G | T | 0.10 (rs4742448) | 0.002 | 0.0004 | 6.5E-08 | 0.002 | 0.0019 | 3.9E-01 | 0.002 | 0.0004 | 4.89E-08 |
| rs117245733 | 13 | 40723944 | G | A | 0.00 (rs7986407) | −0.010 | 0.0017 | 4.2E-09 | −0.024 | 0.0053 | 8.1E-06 | −0.012 | 0.0017 | 3.18E-12 |
| rs10415391 | 19 | 22652436 | C | T | NA | −0.004 | 0.0007 | 2.8E-07 | −0.006 | 0.0028 | 2.0E-02 | −0.004 | 0.0007 | 2.87E-08 |
| rs62132801 | 19 | 49267882 | A | T | NA | 0.004 | 0.0007 | 3.3E-07 | 0.006 | 0.0029 | 2.8E-02 | 0.004 | 0.0007 | 4.20E-08 |