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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Diabetologia. 2018 Jan 10;61(4):906–918. doi: 10.1007/s00125-017-4542-6

Fig. 2.

Fig. 2

Deletion of Sirt6 in pancreatic endocrine progenitor cell leads to glucose intolerance, (a) Blood glucose levels of 2-month-old control (Sirt6f/fand Sirt6 EKO male mice in the fasting or random-fed state (n=6). (b) Plasma insulin levels of 2-month-old control and Sirt6 EKO male mice in the fasting or random-fed state (n=5). (c) Blood glucose after GTTs in 2- to 3-month-old male mice (n=8 control; n=13 EKO). (d) Normalised area under the GTT curve, (e) Plasma insulin levels of 2- to 3-month-old control and Sirt6 EKO mice during the GTT (n=4–6). (f) Glucose tolerance tests of 5- to 6-month-old male mice (n=4 control; n=5 EKO). (g) The normalised area under the GTT curve. Black bars and circles, control mice; grey bars and squares, Sirt6 EKO mice. Data are expressed as means ± SEM. *p<0.05 and **p<0.01 vs control mice or for indicated comparisons