Skip to main content
. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Diabetologia. 2018 Jan 10;61(4):906–918. doi: 10.1007/s00125-017-4542-6

Fig. 5.

Fig. 5

Loss of SIRT6 leads to upregulation of TXNIP. (a, b) Venn diagram (a) and heat map (b) of the overlapped genes between the two Sirt6 KO models from the RNA-Seq analysis. p<1.96×l0−10. (c, d) Immunoblots and quantification (d) of TXNIP expression levels in islets from 3-month-old control (Sirt6f/f) and Sirt6 EKO mice. Data are expressed as means ± SEM (n=3–4). **p<0.01 for indicated comparison