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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Adv Protein Chem Struct Biol. 2017 Oct 6;111:1–59. doi: 10.1016/bs.apcsb.2017.08.003

Fig. 18.

Fig. 18

(A) PPI interface of CD2–CD58 showing electrostatic and hydrophobic interactions. There are 10 salt bridges, 5 hydrogen bonds, and 1 hydrophobic interaction (PDB ID 1QA9). The design of peptides and multicyclic grafted peptide from CD2 adhesion domain based on the interface residues of CD2 of CD2–CD58 interactions. (B) F and C strands from the CD2 protein that interact with CD58. (C) Grafting of CD2 F and C strand residues onto sunflower trypsin inhibitor peptide to generate stable peptides that inhibit PPI of CD2–CD58 for immunomodulation (Sable et al., 2016 ACS Chemical Biology).